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 Table of Contents  
PERSPECTIVE
Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 5-7

Expediency of dengue illness classification: The Sri Lankan perspective


1 Epidemiology Unit, Ministry of Health, Sri Lanka
2 Infectious Disease Hospital, Ministry of Health, Sri Lanka
3 Centre for Clinical Management of Dengue/DHF, District General Hospital Negombo, Ministry of Health, Sri Lanka

Date of Web Publication24-May-2017

Correspondence Address:
Hasitha Tissera
Epidemiology Unit, Ministry of Health, 231 De Saram Place, Colombo 01000
Sri Lanka
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DOI: 10.4103/2224-3151.206884

PMID: 28607248

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How to cite this article:
Tissera H, Weeraman J, Amarasinghe A, Wijewickrama A, Palihawadana P, Fernando L. Expediency of dengue illness classification: The Sri Lankan perspective. WHO South-East Asia J Public Health 2014;3:5-7

How to cite this URL:
Tissera H, Weeraman J, Amarasinghe A, Wijewickrama A, Palihawadana P, Fernando L. Expediency of dengue illness classification: The Sri Lankan perspective. WHO South-East Asia J Public Health [serial online] 2014 [cited 2019 Jul 24];3:5-7. Available from: http://www.who-seajph.org/text.asp?2014/3/1/5/206884




  Dengue classification Top


South-East Asia is the region with the highest burden of dengue,[1] and has been in the forefront of the development of case classification and management.[2] Historically, dengue was considered an incapacitating but largely non-fatal illness. During the late 1950s, outbreaks of fatal haemorrhagic fever in children in Thailand and several other South-East Asian countries changed this perception.[3],[5],[6] Clinical information gathered during these early outbreaks was the basis for dengue clinical classification published in the 1975 World Health Organization (WHO) guidelines, which were subsequently updated in 1997.[7],[8] Dengue illness was classified as two distinct clinical entities: dengue fever (DF) and dengue haemorrhagic fever (DHF). In this classification, the main pathophysiological change differentiating DHF from DF in clinically suspected febrile patients is evidence of progressive and selective plasma leakage lasting 24–48 hours (the critical period”) denoted by haematologicai, radiological and clinical evidence in that order of appearance. It is important to note that this classification served a dual purpose; surveillance and clinical management.

The guidelines for prevention and control of dengue and DHF published by the WHO South-East Asia Regional Office (SEARO) in 2011 further revised the 1997 classification. In this revised classification, DHF was subdivided into non-shock and shock replacing Grades I and II and Grades III and IV, respectively. In addition, unusual manifestations seen among only a minority of patients with severe organ involvement such as liver, kidney, brain or heart (isolated organopathy), associated with dengue illness were classified as expanded dengue syndrome or unusual manifestations.[9]

To address concerns, particularly in clinical settings, regarding application of the 1997/2011 WHO classification the WHO Special Programme for Research and Training in Tropical Diseases (WHO TDR) classification was proposed in 2009[10] and apparently further updated in 2012.[11] This classification defines three different levels of clinical dengue illness: Dengue, Dengue with Warning Signs and Severe Dengue. A study done in Sri Lanka in 2011,[12] which used the 2009 WHO TDR classification because it was more user friendly, found that the majority of DF patients had warning signs. This finding indicates that the warning signs are rather nonspecific. According to the WHO TDR classification, patients with warning signs require strict observation; since these patients form the majority, compliance with the WHO TDR guidance would probably overburden clinical facilities. Furthermore, in the 2009/12 WHO TDR classification “clinical” accumulation of fluid is categorized as a warning sign. However, this physical sign typically presents late and, by the time it is clinically detectable, the patient may already have progressed to impending shock. This predicament has possibly created confusion among clinical practitioners in many countries including Sri Lanka. Therefore, we note that the 2009/12 WHO TDR classification has not given clinicians the anticipated ease of application for successful case management.

Two perspective articles were published recently, entitled “Dogma in classifying dengue disease”,[13] and Dengue: syndromic basis to pathogenesis research inutility of the 2009 WHO case definition”.[14] The authors argued over a number of important issues pertaining to dengue illness classification faced today. From a clinical standpoint it is essential to make all efforts to reduce substantially the morbidity, complications and mortality – whatever the classification used. An informal expert consultation on case management of dengue was held in August 2013 in Colombo, Sri Lanka organized by the WHO SEARO with the participation of country representatives and experts from the region. The overall objective of the meeting was to appraise the current status of the use of case classifications in the region. Here, we briefly describe the best use of these classifications and their challenges in application in the Sri Lankan perspective.


  The Sri Lankan experience Top


Dengue was first serologically confirmed in Sri Lanka in 1962. with the first outbreak reported in 1965.[15] Thereafter, multiple outbreaks of DF were reported with only occasional reporting of DHF, a potentially life-threatening condition. DHF was first reported as a public health problem in Sri Lanka in 1989.[16],[17] Since early 2000, progressively larger epidemics of dengue with more cases of DHF have occurred at regular intervals.[18] A major upward shift to a high incidence of dengue has been reported since 2009, with a markedly high DHF proportion of 10–15%[19]

Classification of dengue illness is important for surveillance and clinical diagnosis and management. The main objective of surveillance is to have a sensitive tool to identify possible dengue cases early for public health intervention. In Sri Lanka, an integrated surveillance system of communicable diseases includes dengue and has island-wide coverage through trained and dedicated clinical and public health staff. National surveillance data are based on timely, high-yield reports that capture symptomatic dengue patients classified by use of the 1997/2011 system. The highest-ever total of 44 461 dengue cases (220 cases/100 000 population) was notified in 2012, approximately a quarter of whom were children younger than 15 years.

Over the past several years a number of activities were initiated in Sri Lanka to strengthen and standardize early detection and management of DHF. The key activities were: development and dissemination of national guidelines; training of all levels of clinical staff based on these guidelines; institutionalization of mandatory patient monitoring charts; capacity building by establishing high-dependency units in major hospitals; and regular clinical and death audits. Furthermore, two centres of excellence were recently established to allow closer observation of children and adults undergoing treatment; hands-on training for clinical staff; and research.

In Sri Lanka, DHF is reported among all age groups from most parts of the country. DHF cases are more common in urban areas with hyperendemic transmission and tend to be younger than DF patients (Epidemiology Unit, unpublished data). We encounter two conflicting clinical practice scenarios. Most practising clinicians actively look for plasma leak among potential leakers” (patients with fever beyond two days with a platelet count dropping towards and below 100 000 mm3) and provide fluid therapy judiciously, based on the haemodynamic status of each patient A minority of clinicians largely depend on warning signs as predictors of severe disease, diagnose severity according to clinical end-points and manage cases accordingly. Most clinicians have realized the importance of detecting plasma leak that is preceded by a drop in platelet count around the time of defervescence. This observation has helped in early differentiation of DHF, thereby minimizing disease severity and the occurrence of complications needing adjunctive therapy. Notably, in a minority of patients with no comorbidities, coinfections or unusual manifestations such as massive blseeding (without leaking), the case-fatality rate remains proportionately higher. This high fatality probably reflects late detection of plasma leakage and therefore delayed initiation of appropriate fluid therapy. This observation supports what Scott Hastead [14] has referred to as clinicians having varying degrees of experience, training and clinical skills that probably influence the disease outcome. We believe Sri Lanka has invested wisely to reach the lowest-ever case-fatality rates of 0.28% in 2013 (from 5% in 1996) against a background of a very high dengue incidence. In our opinion, lowering mortality is a clinician’s top priority and has been handled effectively in Sri Lanka in recent years. Despite this success, some clinicians continue to struggle to classify dengue illness effectively for case management The 1997/2011 WHO classification identifies DF and DHF as two distinct entities; by contrast, the 2009/12 WHO TDR classification considers that “dengue is one disease entity with different clinical presentations and often with unpredictable clinical evolution and outcome”.

In all parts of Sri Lanka, dengue illness is now considered as a differential diagnosis in patients presenting with acute onset of fever with or without classical features of dengue. When there is a mandatory complete blood count done on day 3 of illness onwards, the appearance of leukopenia and subsequent thrombocytopenia aids the diagnosis.[20],[21] Among other criteria, warning signs of severe illness[10] are considered when admitting patients to hospital from day 3 onwards. The relation between the drop in platelet count towards and below 100 000 mm3 with concurrent and consistent haemoconcentration evidenced by a rapid rise in haematocrit towards 20% from the baseline appears to be unique to DHF and helps to distinguish DHF from DF and other acute febrile illnesses.[2] This is the major advantage of the 1997/2011 WHO classification, which has helped to guide clinicians to manage patients without allowing complications of severe dengue to arise, making DHF a “predictably treatable illness”. Furthermore, it is noteworthy that a substantial proportion of patients who develop potentially severe features do not show any of the warning signs described in 2009/12 WHO TDR classification during the febrile phase.

Heavy reliance on warning signs in anticipation of worsening clinical status without a proper monitoring regime has repeatedly been found to result in unwarranted consequences. As rightfully mentioned by Halstead, not all patients as well as treatment centres do equally well. Having reviewed the 1237 dengue-related deaths reported over the past decade in Sri Lanką we are yet to find many cases where the primary cause of death was not related to prolonged and repeated shocks as a consequence of delayed and inappropriate treatment or fluid overload due to over treatment with intravenous fluids without proper monitoring (Epidemiology Unit, unpublished reports). We have observed that the 2009/12 WHO TDR classification provides severity-based end-points (whether natural or iatrogenic) and enables better classification of clinically severe cases. The progressive nature of plasma leak in DHF warrants close clinical and laboratory evaluations and proactive action.[2],[9],[22] Therefore, we reiterate that the main challenge for clinicians is timely decision-making to guide management to handle the fluctuating spectrum of clinical syndrome using the classifications appropriately.

The intention of this Perspective was not to do an exhaustive comparison of the two classifications. No doubt, in terms of surveillance as well as diagnosis and management both classifications have their own advantages and disadvantages. Both classifications were born and do exist under the auspices of the WHO. However, countries with limited logistics and human resources struggle to identify what is best for their own use. It is now time to create a formal platform for both groups to sit around one table together with representatives from countries and develop a common guideline classifying dengue illness best applicable to all. Validation of these classifications as a tool for clinical management should be focused to study the impact of their use in changing the course of the disease and its related outcome.

Source of Support: Nil.

Conflict of Interest: None declared.

Contributorship: All authors have contributed to this paper and have read and approved the final version submitted.



 
  References Top

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Bhatt S, Gething PW, Brandy OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, HoenAG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GRW, Simmons CP, Scott TW, Farrar JJ, Hay Sl”2013! The global distribution and burden of dengue, 2013. Nature. 2013 Apr 25;496(7446):504–7. doi:1038/nature 12060.  Back to cited text no. 1
    
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Cohen SN, Halstead SB. Shock associated with dengue infection. I. The clinical and physiologic manifestations of dengue hemorrhagic fever in Thailand.JPediatr. 1966;68:448–56.  Back to cited text no. 4
    
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Nimmannitya S, Halstead SB, Cohen SN, Margiotta MR. Dengue and chikungunya virus infection in man in Thailand, 1962–1964T I: observations on hospitalized patients with hemorrhagic fever. Am J Trop MedHyg. 1969;18:954–71.  Back to cited text no. 5
    
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Gubler DJ. Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. In: Gubler DJ, Kuno G. editors. Dengue and Dengue Hemorrhagic Fever. Wallingford: CAB International, 1997. pp. 1–22.  Back to cited text no. 6
    
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World Health Organization, Regional Offices for South-East Asian, Western Pacific Regional Office. Technical guidelines for diagnosis, treatment, surveillance, prevention and control of dengue haemorrhagic fever. New Delhi: WHO-SEARO, 1975.  Back to cited text no. 7
    
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World Health Organization. Dengue hemorrhagic fever: diagnosis, treatment, prevention and control. Geneva: WHO, 1997.  Back to cited text no. 8
    
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World Health Organization, Regional Office for South-East Asia. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever. New Delhi: WHO-SEARO, 2011.  Back to cited text no. 9
    
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World Health Organization, Special Programme for Research and Training in Tropical Diseases (TDR). Dengue guidelines for diagnosis, treatment, prevention and control. Geneva: WFFO, 2009. Document No.WHO/HTM^TD/DEN/2009.1.  Back to cited text no. 10
    
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World Health Organization, Special Program for Research and Training in Tropical Diseases (TDR). Handbook for clinical management of dengue. Geneva: WHO, 2012.  Back to cited text no. 11
    
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Wanigasuriya K, Guruge P, Wijewickrama A, Seneviratne SL, Gunatilake SB. Usefulness of World Health Organization (WHO) dengue case classifications in a Sri Lankan clinical setting. Journal of the Ceylon College of Physicians. 2011;42:21–27.  Back to cited text no. 12
    
13.
Farrar JJ, Hien TT, Horstick O, Hung NT, Jaenisch T, Junghanns T Kroeger A, Laksono IS, Lum L, Martinez E, Simmons CP, Tami A, Tomashek KM, Wills BA. Dogma in classifying dengue disease. Am J Trop Med Hyg. 2013 Aug;89(2):198–201.  Back to cited text no. 13
    
14.
Halstead SB. Dengue: the syndromic basis to pathogenesis research, inutility of the 2009 WHO case definition. Am J Trop Med Uyg. 2013;88:212–215.  Back to cited text no. 14
    
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Vitarana T. Viral diseases in Sri Lanka: a national overview. In: Viral diseases in south east asia and the western pacific. Mackenzie JS. Editor. London: Academic Press, 1982. pp. 198–204.  Back to cited text no. 15
    
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Vitarana T, Jayakuru WS, Withane N. Historical account of dengue haemorrhagic fever in Sri Lanka. Dengue Bulletin. 1997;21:117–8.  Back to cited text no. 16
    
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Kulatilaka TA, Jayakuru ws. Control of dengue/dengue haemorrhagic fever in Sri Lanka. Dengue Bulletin. 1998;22: 53–9.  Back to cited text no. 17
    
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Kanakaratne N, Wahala MPBW, Messer WB, Tissera HA, Shahani A Abeysinghe N, De Silva AM, Gunasekera M. Severe dengue epidemics in Sri Lanka, 2003–2006. Emerging Infectious Diseases. 2009;15(2): 192–199.  Back to cited text no. 18
    
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Sri Lanka, Ministry of Health. Special report: dengue fever/dengue haemorrhagic fever surveillance 2011. Epidemiological Bulletin. 2012; 53(3):17–19.  Back to cited text no. 19
    
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21.
Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai w, Ratanachu-eke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA. Early clinical and laboratory indicators of acute dengue illness. Journal of Infectious Diseases. 1997;176:313–321.  Back to cited text no. 21
    
22.
Nimmannitya s. Dengue hemorrhagic fever: diagnosis and management. In: Dengue and dengue hemorrhagic fever. Gubler DJ, Kuno G. Editors. Walling ford UK, New York: CAB International, 1997. pp. 133–145.  Back to cited text no. 22
    



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